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Sorafenib Hemi-Tosylate Monohydrate

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N° de SZ CAT SZ-S012020
Número CAS 1908433-49-7
Mol.F. C21H16ClF3N4O3 : 1/2(C7H8O3S) : H2O
Peso Molecular 464.8 : 1/2(172.2) : 18.0
Status de Fatura Custom Synthesis
Rel. CAS No 475207-59-1 (Tosylate salt) ; 1199618-57-9 (HCl salt) ; 284461-73-0 (free base) ; 1280217-32-4 (sulfate salt)


Disclaimer

SynZeal product information given on this website is as per the existing understanding while publishing the details on website. The customer is responsible for assessing the accuracy of the information at the time of actual purchase.

SynZeal will update these details as per new development or finding in product specification without further noticed.

Nome Químico: 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide hemitosylate monohydrate(as per EP);4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide hemitosylate monohydrate (as per USP)

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Sorrisos: CNC(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=CC=N1)=O.O=[S](O)(C(C=C4)=CC=C4C)=O.O

Sorafenib Hemi-Tosylate Monohydrate is chemically 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide hemitosylate monohydrate(as per EP);4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide hemitosylate monohydrate (as per USP). Sorafenib Hemi-Tosylate Monohydrate is supplied with detailed characterization data compliant with regulatory guideline. Sorafenib Hemi-Tosylate Monohydrate can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Sorafenib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
 
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185

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