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化学名称: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-Ethyl-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
异名: Ascomycin ; Tacrolimus USP RC A ; Tacrolimus Desmethylene Impurity ; Immunomycin
Shipping Temperature: Ambient
HSN Code: 38229010
Country of Origin: India
微笑: O=C(C([C@]1(O)O[C@]([H])([C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]2CC)[C@@H](OC)C[C@H]1C)=O)N3CCCC[C@@]3([H])C(O[C@H](/C(C)=C/[C@@H]4CC[C@@H](O)[C@H](OC)C4)[C@H](C)[C@@H](O)CC2=O)=O
Ascomycin is chemically (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-Ethyl-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone. It is also known as Ascomycin ; Tacrolimus USP RC A ; Tacrolimus Desmethylene Impurity ; Immunomycin. Ascomycin is supplied with detailed characterization data compliant with regulatory guideline. Ascomycin can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Ascomycin.
The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.
Analysis of ascomycin production enhanced by shikimic acid resistance and addition in Streptomyces hygroscopicus var. ascomyceticus
Haishan Qi a, Sumin Zhaoa, Jianping Wena,b,c,∗, Yunlin Chend, Xiaoqiang Jia
Biochemical Engineering Journal 82 (2014) 124–133
Highly Chemoselective Trichloroacetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosuppressant L-733,725
Zhiguo Song,* Anthony DeMarco, Mangzhu Zhao, Edward G. Corley, Andrew S. Thompson, James McNamara, Yulan Li, Dale Rieger, Paul Sohar, David J. Mathre, David M. Tschaen, Robert A. Reamer, Martha F. Huntington, Guo-Jie Ho, Fuh-Rong Tsay, Khateeta Emerson, Richard Shuman, Edward J. J. Grabowski, and Paul J. Reider
J. Org. Chem. 1999, 64, 1859-1867
Chemistry of the Immunomodulatory Macrolide Ascomycin and Related Analogues
Murty A.R.C. Bulusu, Karl Baumann, and Anton Stuetz
A.D. Kinghorn, H. Falk, J. Kobayashi (eds.), Progress in the Chemistry of Organic Natural Products, Vol. 94,
Enhancement of ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by combining resin HP20 addition and metabolic profiling analysis
Haishan Qi, Sumin Zhao, Hong Fu, Jianping Wen, Xiaoqiang Jia
Journal of Industrial Microbiology and Biotechnology, Volume 41, Issue 9, 1 September 2014, Pages 1365–1374
