Hydrochlorothiazide 5-Chloro Impurity

Hydrochlorothiazide 5-Chloro Impurity is chemically 5,6-Dichloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide ;. It is also known as 5-Chloro Hydrochlorothiazide. Hydrochlorothiazide 5-Chloro Impurity is supplied with detailed characterization data compliant with regulatory guideline. Hydrochlorothiazide 5-Chloro Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Hydrochlorothiazide.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Purification and identification of an impurity in bulk hydrochlorothiazide
xueguang fang,1 richard todd bibart,1 suzanne mayr,1 winnie yin,1 paul a. harmon,2 jennifer finnegan mccafferty,3 r. jeffrey tyrrell,4 robert a. reed
journal of pharmaceutical sciences, vol. 90, no. 11, november 2001
 
Simultaneous Determination of Hydrochlorothiazide and Benazepril Hydrochloride or Amiloride Hydrochloride in Presence of Hydrochlorothiazide Impurities: Chlorothiazide and Salamide by HPTLC Method
Ibrahim A. Naguib1, Eglal A. Abdelaleem1, Hala E. Zaazaa2 and Mohammed E. Draz
Journal of Chromatographic Science 2014;1–6
 
A Validated High-Performance Thin-Layer Chromatographic Method for the Simultaneous Determination of Zofenopril Calcium and Hydrochlorothiazide in the Presence of the Hydrochlorothiazide Impurities: Chlorothiazide and Salamide
Mamdouh R Rezk, Ahmed S Fayed, Hoda M Marzouk, Samah S Abbas
Journal of AOAC International, Volume 101, Issue 4, 1 July 2018, Pages 1031–1041
 
An improved validated HPLC method for separation of metoprolol and hydrochlorothiazide impurities in metoprolol and hydrochlorothiazide tablets
Avinash S. Patil1 , Shakil S. Sait2 , Abhijit Deshamukh1 and Girish Deshpande1
Der Pharmacia Lettre, 2015, 7 (2):183-190
 
Method Development and Validation for the Determination of Potential Impurities Present in Olmesartan Medoxomil and Hydrochlorothiazide in Fixed Dose Combination Drug Product by Using Reverse Phase – Ultra-Performance Liquid Chromatography Coupled with Diode-Array Detector
R. srikanth reddy,1 r. murali krishna,2 n. a. vekaria,1 sumathi v. rao,1 and bhaskara p. v. mantena1
Journal of Liquid Chromatography & Related Technologies, 38: 1343–1354, 2015

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