Nadolol EP Impurity C

Nadolol EP Impurity C is chemically 5,5′-[(2rs)-2-Hydroxypropane-1,3-diylbis(oxy)]bis(cis-1,2,3,4-tetrahydronaphthalene-2,3-diol)  (as per EP). Nadolol EP Impurity C is supplied with detailed characterization data compliant with regulatory guideline. Nadolol EP Impurity C can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Nadolol.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Nadolol: high-pressure liquid chromatographic methods for assay, racemate composition and related compounds
pauline m. lacroix,t norman m. curran and edward g. lovering
Journal of Pharmaceutical & Biomedical Analysis Vol. 10, Nos 10-12, pp. 917-924, 1992
 
The nonmetabolized β‑blocker nadolol is a substrate of oct1, oct2, mate1, mate2-k, and p‑glycoprotein, but not of oatp1b1 and oatp1b3
Shingen Misaka, Jana Knop, Katrin Singer, Eva Hoier, Markus Keiser, Fabian Müller, Hartmut Glaeser, Jö rg Kö nig, and Martin F. Fromm
Mol. Pharmaceutics 2016, 13, 2, 512–519
 
Separation of nadolol racemates by high pH reversed-phase preparative chromatography
Rami S. Arafaha,b , António E. Ribeiroa,b , Alírio E. Rodriguesc , Luís S. Pais
Separation and Purification Technology Volume 233, 15 February 2020, 116018

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