Furosemide Acyl-β-D-glucuronide

SZ CAT No:	SZ-F032024
CAS No	72967-59-0
Mol.F.	C18H19ClN2O11S
Mol.Wt.	506.9
Inv. Status	Custom Synthesis

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Chemical Name: (2S,3S,4S,5R,6S)-6-((4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(C(C=C1[S](N)(=O)=O)=C(C=C1Cl)NCC2=CC=CO2)O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)C(O)=O

A New Way of Stabilization of Furosemide upon Cryogenic Grinding by Using Acylated Saccharides Matrices. The Role of Hydrogen Bonds in Decomposition Mechanism
E. Kaminska,*,† K. Adrjanowicz,‡,§ K. Kaminski,§,∥ P. Wlodarczyk,⊥ L. Hawelek,§,⊥ K. Kolodziejczyk,§ M. Tarnacka,§ D. Zakowiecki,# I. Kaczmarczyk-Sedlak,† J. Pilch,∇ and M. Paluch
Mol. Pharmaceutics 2013, 10, 5, 1824–1835

Effect of Cryogrinding on Chemical Stability of the Sparingly Water-Soluble Drug Furosemide
Karolina Adrjanowicz, Kamil Kaminski, Katarzyna Grzybowska, Lukasz Hawelek, Marian Paluch, Irena Gruszka, Daniel Zakowiecki, Wieslaw Sawicki, Przemyslaw Lepek, Wojciech Kamysz & Lukasz Guzik
Pharmaceutical Research volume 28, pages3220–3236(2011)

Implementation of design of experiments for optimization of forced degradation conditions and development of a stability-indicating method for furosemide
MoolchandKurmiaSanjayKumaraBhupinderSinghbSaranjitSingh
Journal of Pharmaceutical and Biomedical Analysis Volume 96, 5 August 2014, Pages 135-143

Furosemide Determination by First‐Derivative Spectrophotometric Method
Iara Lu´cia Tescarollo Dias, Jorge Luiz S. Martins, Graciliano de Oliveira Neto
Analytical Letters, 38: 1159–1166, 2005

Furosemide Acyl-β-D-glucuronide is chemically (2S,3S,4S,5R,6S)-6-((4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid. Furosemide Acyl-β-D-glucuronide is supplied with detailed characterization data compliant with regulatory guideline. Furosemide Acyl-β-D-glucuronide can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Furosemide.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.