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Tacrolimus 21-Carboxylic Acid Impurity

Picture of Tacrolimus 21-Carboxylic Acid Impurity
SZ CAT No SZ-T005010
CAS No NA
Mol.F. C44H71NO13
Mol.Wt. 822.1
Inv. Status Custom Synthesis


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SynZeal will update these details as per new development or finding in product specification without further noticed.

Chemical Name: 2-((2R,3R,5S)-6-((1S,3S,5Z,7R,10S,11R,12S,13E)-7-Allyl-10-hydroxy-14-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methoxy-3,5,11,13-tetramethyl-8-oxo-12-(((S)-piperidine-2-carbonyl)oxy)tetradeca-5,13-dien-1-yl)-2-hydroxy-5-methoxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetic acid

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: OC(C([C@]1(O)OC([C@@H](OC)C[C@@H](C)C/C(C)=C\[C@@H](CC=C)C(C[C@H](O)[C@@H](C)[C@@H](/C(C)=C/[C@@H]2CC[C@@H](O)[C@H](OC)C2)OC([C@@]3([H])NCCCC3)=O)=O)[C@@H](OC)C[C@H]1C)=O)=O

Tacrolimus 21-Carboxylic Acid Impurity is chemically 2-((2R,3R,5S)-6-((1S,3S,5Z,7R,10S,11R,12S,13E)-7-Allyl-10-hydroxy-14-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methoxy-3,5,11,13-tetramethyl-8-oxo-12-(((S)-piperidine-2-carbonyl)oxy)tetradeca-5,13-dien-1-yl)-2-hydroxy-5-methoxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetic acid. Tacrolimus 21-Carboxylic Acid Impurity is supplied with detailed characterization data compliant with regulatory guideline. Tacrolimus 21-Carboxylic Acid Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tacrolimus.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Development and validation of a stability indicating HPLC assay method for tacrolimus in semi-​solid dosage form & bulk drug
By Gejage, Santosh; Amin, Purnima
From Indo American Journal of Pharmaceutical Research (2018), 8(5), 1097-1106

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  • In Stock product will dispatch in 24 h after receipt of purchase order. It usually take 2-3 days to receive products in India and 5-6 working days for export customer depending on destination.
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