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化学名称: (3R,5R)-5-([1.1'-Biphenyl]-4-ylmethyl)-3-methylpyrrolidin-2-one
Shipping Temperature: Ambient
HSN Code: 38229010
Country of Origin: India
微笑: O=C1N[C@@H](CC2=CC=C(C3=CC=CC=C3)C=C2)C[C@H]1C
下载MSDS
A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impuritiesLu Zhou, Liang Zou, Lili Sun, Hui Zhang, Wenkai Hui and Qiaogen ZouAnal. Methods, 2018,10, 1046-1053 Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MSRavi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelviMaterials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645 Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation KineticsBahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. MahmoudChromatographia volume 81, pages139–156(2018) Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation productsPintu Prajapati, Dhara Bhayani, Priti Mehta.J App Pharm Sci. 2020; 10(2): 97-107
Sacubitril Impurity 28 is chemically (3R,5R)-5-([1.1'-Biphenyl]-4-ylmethyl)-3-methylpyrrolidin-2-one. Sacubitril Impurity 28 is supplied with detailed characterization data compliant with regulatory guideline. Sacubitril Impurity 28 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Sacubitril.
The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.
Sacubitril Calcium
Sacubitril-(2S,4S)-Isomer
Sacubitril-(2R,4R)-Isomer
Sacubitril (3R,5S)-Pyrrolidinone Impurity
2,5-Dioxopyrrolidine Sacubitril
Sacubitrilat
Sacubitril Impurity 5
Sacubitril Impurity 6
Sacubitril Impurity 7
Sacubitril Impurity 8
Sacubitril Impurity 9
Sacubitril Impurity 10
Sacubitril Impurity 11
Sacubitril Impurity 12
Sacubitril Impurity 13
Sacubitril Impurity 14
Sacubitril Impurity 15
Sacubitril Impurity 16
Sacubitril Impurity 17
Sacubitril Impurity 18
Sacubitril Impurity 19
Sacubitril Impurity 20
Sacubitril Impurity 21
Sacubitril Impurity 22
Sacubitril Impurity 23
Sacubitril Impurity 24
Sacubitril Maleic Acid (E-Isomer)
Sacubitril Methyl Ester
(2R,4S)-Sacubitril
Sacubitril Impurity 25
Sacubitril D4
(2S,4S)-Sacubitril D4
Sacubitril Impurity 26
Sacubitril Impurity 28
Sacubitril Impurity 31
Sacubitril Impurity 30
Valsartan Sacubitril
Sacubitril Impurity 32
Sacubitril Sodium
Sacubitril Impurity 33
Sacubitril Impurity 34
Sacubitril Impurity 35
Sacubitril N-Acetyl Impurity
Sacubitril Propyl Ester
Sacubitril Impurity 36
Sacubitril TBA Salt
Sacubitril Impurity 37
Sacubitril
Sacubitril Impurity 38
Sacubitril Impurity 40
Sacubitril Impurity 41
Sacubitril Impurity 42
Sacubitril Impurity 43
N-Nitroso Sacubitril Valsartan
N-Nitroso Sacubitril
Sacubitril Maleic Acid (Z-Isomer)
Sacubitrilat-13C4
N-Nitroso Sacubitril Impurity 1