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Docetaxel EP Impurity D

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SZ CAT No:	SZ-D031005
CAS No	162784-72-7
Mol.F.	C43H51NO14
Mol.Wt.	805.9
Inv. Status	In Stock

Product Overview Description Technical Data

Chemical Name: 5β,20-Epoxy-1,7α-dihydroxy-9,10-dioxotax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate] (as per EP)(2aR,4R,4aS,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4, 9,11,12,12b-pentahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5,6-dione 12b-acetate, 12-benzoate, 9-ester (as per USP)

Synonym: 4-Epi-6-Oxo Docetaxel (USP) ; 10-Deoxy-10-Oxo-7-epi-Docetaxel (EP)

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(C)O[C@@]1([C@](C[C@H]2O)([H])OC1)[C@@]([C@@]2(C3=O)C)([H])[C@@H]([C@@](C4(C)C)(C[C@H](OC([C@H](O)[C@H](C5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C(C)=C4C3=O)O)OC(C6=CC=CC=C6)=O

Development and validation of RP-HPLC method for simultaneous estimation of docetaxel and ritonavir in PLGA nanoparticles
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By Kumbhar, P. S.; Diwate, Sonali K.; Mali, U. G.; Shinde, T. U.; Disouza, J. I.; Manjappa, A. S.
From Annales Pharmaceutiques Francaises (2020), 78(5), 398-407

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Docetaxel EP Impurity D

SZ CAT No:	SZ-D031005
CAS No	162784-72-7
Mol.F.	C43H51NO14
Mol.Wt.	805.9
Inv. Status	In Stock

Disclaimer

SynZeal will update these details as per new development or finding in product specification without further noticed.

Synonym: 4-Epi-6-Oxo Docetaxel (USP) ; 10-Deoxy-10-Oxo-7-epi-Docetaxel (EP)

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(C)O[C@@]1([C@](C[C@H]2O)([H])OC1)[C@@]([C@@]2(C3=O)C)([H])[C@@H]([C@@](C4(C)C)(C[C@H](OC([C@H](O)[C@H](C5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C(C)=C4C3=O)O)OC(C6=CC=CC=C6)=O

Docetaxel EP Impurity D is chemically 5β,20-Epoxy-1,7α-dihydroxy-9,10-dioxotax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate] (as per EP)(2aR,4R,4aS,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4, 9,11,12,12b-pentahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5,6-dione 12b-acetate, 12-benzoate, 9-ester (as per USP). It is also known as 4-Epi-6-Oxo Docetaxel (USP) ; 10-Deoxy-10-Oxo-7-epi-Docetaxel (EP). Docetaxel EP Impurity D is supplied with detailed characterization data compliant with regulatory guideline. Docetaxel EP Impurity D can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Docetaxel.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.